温小安1976年出生,研究员,博士生导师,主要从事抗代谢性疾病和抗肿瘤药物研究。2007年毕业于中国药科大学药物化学专业,获博士学位。2009年获第12届中国药学会-施维雅青年药物化学奖、全国优秀博士学位论文提名奖。2010-2012年获FFCSA(法中科学及应用基金会)资助,在法国里尔二大从事博士后研究。目前主持国家自然科学基金、江苏省自然科学基金等多项科研项目。

代表性论文:

1. Xiaowei Sun, Xiaoan Wen (共一作), Yan-yan Chen, Chen Shi, Chengzhe Gao, Yong Wu, Li-jun Wang, Xiu-hong Yang*, Hongbin Sun*. Discovery of highly potent renin inhibitors potentially interacting with the S3’ subsite of renin. European Journal of Medicinal Chemistry 2015, 103, 269–288.

2. Zeng-Wei Lai, Chunhong Li, Jun Liu, Lingyi Kong, Xiaoan Wen*, Hongbin Sun*. Discovery of highly potent DPP-4 inhibitors by hybrid compound design based on linagliptin and alogliptin. European Journal of Medicinal Chemistry 2014, 83, 547–560.

3. Jizhe Dong, Yanchun Gong, Jun Liu, Xiangfeng Chen, Xiaoan Wen*, Hongbin Sun*. Synthesis and biological evaluation of all eight stereoisomers of DPP-IV inhibitor saxagliptin. Bioorganic & Medicinal Chemistry 2014, 22, 1383–1393.

4. Xiaowei Sun, Chengzhe Gao, Fan Zhang, Zhuang Song, Lingyi Kong,Xiaoan Wen*, Hongbin Sun*. Electronic and steric effects on the intramolecular Schmidt reaction of alkyl azides with secondary benzyl alcohols. Tetrahedron 2014,70, 643–649.

5. Xiaoan Wen, Hongbin Sun*, Jun Liu, Keguang Cheng, Pu Zhang, Liying Zhang, Jia Hao, Luyong Zhang, Peizhou Ni, Spyros E. Zographos, Demetres D. Leonidas, Kyra-Melinda Alexacou, Thanasis Gimisis, Joseph M. Hayes, Nikos G. Oikonomakos*. Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies. Journal of Medicinal Chemistry 2008, 51, 3540–3554.

联系方式:

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通信地址:南京市童家巷24号,中国药科大学研究生科研大楼1805室,邮编:210009